SISTEM PENGENDALIAN AQUARIUM DAN PEMBERIAN PAKAN IKAN SECARA OTOMATIS BERBASIS MIKROKONTROLER

Pada perkembangannya kebutuhan akan teknologi komputer dirasa semakin penting, dan tidak hanya dalam satu bidang saja tapi semua bidang membutuhkan teknologi. Darisanalah muncul ide untuk mengoperasikan suatu sistem dengan menggunakan teknologi, khususnya teknologi komputer. Sistem pengontrolan yang dilakukan oleh komputer akan menjadi lebih baik, cepat, tepat, aman, praktis, dan banyak lagi keuntungan lain yang didapatkan dari pada menggunakan cara manual. Dari beberapa keuntungan tersebut dapat dijadikan syarat untuk mewujudkan “Sistem Pengendalian Ruang Budidaya dan Pemberian Pakan Ikan secara Otomatis Berbasis Mikrokontroler”. Pemeliharaan ikan secara otomatis oleh sistem pengontrol akan memudahkan para penggemar ikan dalam pemeliharaan ikan, terutama pada saat ikan tersebut di tinggal oleh pemiliknya. Secara umum sistem ini telah dilengkapi oleh fasilitas pengontrol secara hardware maupun software sehingga dengan Tugas Akhir ini diharapkan dapat memberi ide untuk mengoptimalkan penggunaan fasilitas kontrol tersebut

Faktor-Faktor Yang Mempengaruhi Siswa-Siswa SMU/SMK Terhadap Keputusan Pemilihan Perguruan Tinggi Swasta

Perguruan tinggi swasta merupakan salah satu alternatif pilihan bagi siswa yang ingin melanjutkan pendidikannya ke jenjang yang lebih tinggi selain perguruan tinggi negeri. Jumlah PTS sangat banyak dan menyebar diseluruh wilayah, sehingga siswa bebas dalam melakukan pemilihan PTS mana yang akan dituju. Untuk mengetahui faktor – faktor apa yang mempengaruhi keputusan siswa dalam memilih PTS maka dilakukan penelitian ini.Penelitian dilakukan diwilayah kabupaten bekasi. Penelitian ini menggambil 4 sampel SMAN di Kabupaten Bekasi yaitu SMAN 2 Tambun Selatan, SMAN 1 Tambun Utara, SMAN 1 Cikarang Pusat dan SMAN 1 Babelan. Responden dalam penelitian ini adalah siswa dengan jumlah total 1.260 siswa. Metode pengolahan data dilakukan dengan menggunakan statistik multivariat yaitu analisis faktor dengan bantuan software SPSS.Hasil analisis menunjukan kuesioner dengan 20 variabel digunakan untuk mencari faktor yang mempengaruhi siswa dalam memilih Perguruan Tinggi Swasta. Faktor yang mencakup pada variabel tersebut adalah faktor ekonomi, faktor Perguruan Tinggi, faktor lingkungan dan faktor promosi. Terdapat 2 komponen sesuai hasil bobot faktor yaitu alasan utama dan daya tarik. Dari kedua faktor alasan tersebut maka diperoleh bahwa faktor utamanya adalah media dalam mencari perguruan tinggi dengan nilai faktor 0,953 dan faktor daya tariknya adalah transportasi menuju kampus dengan nilai faktor 0,904

The use of RGB Imaging and FTIR Sensors for mineral mapping in the Reiche Zeche underground test mine, Freiberg

The application of sensor technologies for raw material characterization is rapidly growing, and innovative advancement of the technologies is observed. Sensors are being used as laboratory and in-situ techniques for characterization and definition of raw material properties. However, application of sensor technologies for underground mining resource extraction is very limited and highly dependent on the geological and operational environment. In this study the potential of RGB imaging and FTIR spectroscopy for the characterization of polymetallic sulphide minerals in a test case of Freiberg mine was investigated. A defined imaging procedure was used to acquire RGB images. The images were georeferenced, mosaicked and a mineral map was produced using a supervised image classification technique. Five mineral types have been identified and the overall classification accuracy shows the potential of the technique for the delineation of sulphide ores in an underground mine. FTIR data in combination with chemometric techniques were evaluated for discrimination of the test case materials. Experimental design was implemented in order to identify optimal pre-processing strategies. Using the processed data, PLS-DA classification models were developed to assess the capability of the model to discriminate the three material types. The acquired calibration and prediction statistics show the approach is efficient and provides acceptable classification success. In addition, important variables (wavelength location) responsible for the discrimination of the three materials type were identified

Long-duration laboratory experiment of slow development of steady alternate bars

River morphodynamics and sediment transportRiver morphology and morphodynamic

Mechanistic Assessment of Extrahepatic Contributions to Glucuronidation of Integrase Strand Transfer Inhibitors

Integrase strand transfer inhibitor (INSTI)-based regimens dominate initial human immunodeficiency virus treatment. Most INSTIs are metabolized predominantly via UDP-glucuronosyltransferases (UGTs). For drugs predominantly metabolized by UGTs, including INSTIs, in vitro data recovered from human liver microsomes (HLMs) alone often underpredict human oral clearance. While several factors may contribute, extrahepatic glucuronidation may contribute to this underprediction. Thus, we comprehensively characterized the kinetics for the glucuronidation of INSTIs (cabotegravir, dolutegravir, and raltegravir) using pooled human microsomal preparations from liver (HLMs), intestine (HIMs), and kidney (HKMs) tissues; human embryonic kidney 293 cells expressing individual UGTs; and recombinant UGTs. In vitro glucuronidation of cabotegravir (HLMs≈HKMs>>>HIMs), dolutegravir (HLMs>HIMs>>HKMs), and raltegravir (HLMs>HKMs>> HIMs) occurred in hepatic and extrahepatic tissues. The kinetic data from expression systems suggested the major enzymes in each tissue: hepatic UGT1A9 > UGT1A1 (dolutegravir and raltegravir) and UGT1A1 (cabotegravir), intestinal UGT1A3 > UGT1A8 > UGT1A1 (dolutegravir) and UGT1A8 > UGT1A1 (raltegravir), and renal UGT1A9 (dolutegravir and raltegravir). Enzymes catalyzing cabotegravir glucuronidation in the kidney and intestine could not be identified unequivocally. Using data from dolutegravir glucuronidation as a prototype, a "bottom-up" physiologically based pharmacokinetic model was developed in a stepwise approach and predicted dolutegravir oral clearance within 4.5-fold (hepatic data only), 2-fold (hepatic and intestinal data), and 32% (hepatic, intestinal, and renal data). These results suggest clinically meaningful glucuronidation of dolutegravir in tissues other than the liver. Incorporation of additional novel mechanistic and physiologic underpinnings of dolutegravir metabolism along with in silico approaches appears to be a powerful tool to accurately predict the clearance of dolutegravir from in vitro data

Age-Related Changes in MicroRNA Expression and Pharmacogenes in Human Liver

Developmental changes in the liver can significantly impact drug disposition. Due to the emergence of microRNAs (miRNAs) as important regulators of drug disposition gene expression, we studied age-dependent changes in miRNA expression. Expression of 533 miRNAs was measured in 90 human liver tissues (fetal, pediatric [1-17 years], and adult [28-80 years]; n = 30 each). In all, 114 miRNAs were upregulated and 72 were downregulated from fetal to pediatric, and 2 and 3, respectively, from pediatric to adult. Among the developmentally changing miRNAs, 99 miRNA-mRNA interactions were predicted or experimentally validated (e.g., hsa-miR-125b-5p-CYP1A1; hsa-miR-34a-5p-HNF4A). In human liver samples (n = 10 each), analyzed by RNA-sequencing, significant negative correlations were observed between the expression of >1,000 miRNAs and mRNAs of drug disposition and regulatory genes. Our data suggest a mechanism for the marked changes in hepatic gene expression between the fetal and pediatric developmental periods, and support a role for these age-dependent miRNAs in regulating drug disposition